Why Does Hyperuricemia Not Necessarily Induce Gout?

Hyperuricemia is a risk factor for gout. It has been well observed that large proportion of individuals with hyperuricemia have never had gout flare(s), while some patients can normuricemia. This raises puzzle the real role serum uric acid (SUA) in occurrence flares. As molecule its dual effects vivo antioxidant properties as being an inflammatory promoter, it placed delicate position balancing metabolisms. Gout seems to be multifactorial metabolic disease and pathogenesis should not rely solely on or monosodium urate (MSU) crystals. critical review aims unfold mechanisms SUA participating development. also discusses key elements which are prerequisites formation association current therapeutic regime. The compilation helpful precisely fighting cure clinically pharmaceutically.